Welcome
To
21st Century smART Male Fertility Testing
The most comprehensive male fertility testing presently available
About Us
Our Team
Our Team
Our Team
Dr. David Brown CEO/Inventor: https://www.linkedin.com/in/david-brown-ph-d-7b32266/
Our Team
Our Team
Our Team
Derek Delanski BD Specialist:
Our Team
Our Team
Our Team
Tania Rodriguez Clinical Technologist:
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Announce coming events
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Testimonial #1
"I wish this was an option prior to IVF procedures as we had multiple miscarriage's while trying to conceive." -Derek and Jane
Testimonial #2
If this was an option when we went through IVF we gladly would have paid out of pocket to assist us in getting our twins!" -Crystal and Richard
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Details of services
Male Fertility Diagnostics offers the Sperm DNA Accelerated Decondensation (SDAD) and Sperm DNA Decondensation (SDD) tests, and Sperm Chromatin Fragmentation Assay (SCFA) in partnership with Unilab of Dade.
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FAQs/Reviews
Proprietary Testing to Help Determine the Next Step
SDAD and SDD Services
Sperm DNA Decondensation Test (SDD) and Sperm DNA Accelerated Decondensation (SDAD). Once a sperm has fertilized an egg, the DNA message must go through a transformation process in order for it to successfully combine with the egg's DNA message. The first step in this process is called decondensation. These tests assess whether or not the sperm DNA goes through the normal decondensation process. Failure to go through the normal process may result in a partially or completely unreadable DNA message, leading to an increased chance of early pregnancy loss or no pregnancy at all.
SCFA Services
Sperm Chromatin Fragmentation Assay (SCFA). This test assesses the physical structure of sperm DNA. If there is too much damage (aka DNA breaks) to key parts of the DNA message, then it may be rendered either partially or completely unreliable and the pregnancy may terminate or not occur at all.
Percentage of Male Factor Infertility Issues Identified by the Male Reproductive Health Panel (MRHP) of Tests
The MRHP detects the highest percentage of male factor infertility compared to any stand alone test. The SDAD Test will identify 6.9% of infertile couples as having male factor issues related to ROS damaged sperm. The combined use of the SDD Test and the SCFA will identify 41.9% of infertile couples as having compromised SPERM DNA INTEGRITY (21%) and/or SPERM FUNCTION issues related to pronucleus formation/DNA reformatting (20.9%). If just the SCFA is performed, only 21.0% of infertile couples with male factor infertility issues will be identified.
Male Factor Infertility Diagnostics
References:
- 1. World Heath Organization. Towards more objectivity in diagnosis of male infertility. Int J Androl 1987;7:1-53
- 2. Tirado EE, and Brown DB. Effects of in vivo oxidative stress generated during acute/infection/inflammation on human sperm activation. Abstract presented at the 60th annual American Society for Reproductive Medicine (ASRM) meeting (October 17-20, 2004), Philadelphia, PA, Poster 144: Fert. Steril. 82 (Suppl 2): S185, 2004.
- 3. Brown DB, Merryman, DC, Rivnay B, Houserman VL, Long CE, and Honea KL. Evaluating a novel panel of sperm function tests for utility in predicting intracytoplasmic sperm injection (ICSI) outcome. J Assist Reprod Genet 2013; 30:461-477.
- 4. Brown DB, Gelman KM, Whitman-Elia GF, Witt MA, Kordus RJ, and Roseff SJ. Comparing the Sperm DNA Decondensation (SDD) and Sperm DNA Accelerated Decondensation (SDAD) tests’ capacity for identifying infertile males likely to benefit from Anti-Oxidant treatment. Abstract presented at the 66th annual American Society for Reproductive Medicine (ASRM) meeting (October 23-27, 2010), Denver, CO, Poster 503: Fert. Steril. 94 (Suppl 4): S238, 2010.
- 5. Brown DB, Hayes E, Uchida T, and Nagamani M. Some cases of human male infertility are explained by abnormal in vitro human sperm activation. Fertility and Sterility 1995; 64(3): 612-622.
- 6. Anderson A, Rivnay, B, Crain J, and Leader B. Sperm DNA decondensation assay and selection of assisted reproductive technology method, Fertility and Sterility, Volume 88, Supp. 1, September 2007, S377-S378.
- 7. United States Patent No.: US 9,157,909 B2: “Male Reproductive Health Panel and Uses Thereof.” Issued: October 13, 2015. Inventor: David B. Brown.
- 8. Evenson D, Jost L, Zinaman M et al. Utility of the sperm chromatin structure assay (SCSA) as a diagnostic and prognostic tool in the human fertility clinic. Human Reproduction 1999; 14: 1039-1049.
- 9. Larsen-Cook KL, et al. Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay. Fertility and Sterility 2003; 80: 895-902.
- 10. Bungum M et al. Sperm DNA Integrity assessment in prediction of assisted reproductive technology outcome. Human Reproduction 2007; 22:174-9.